Loss of specific lamins does not affect protein levels of other lamins we analyzed the function of specific lamins in nuclear shape stability and stiffness in wild type mefs and in mefs lacking lamin a designated lamin c only or lmna lco lco cells in mefs deficient in both lamins a and c lmna and in mefs expressing a severely truncated mutant form of lamin b1 lmnb1. Lamins also known as nuclear lamins are fibrous proteins in type v intermediate filaments providing structural function and transcriptional regulation in the cell nucleus nuclear lamins interact with inner nuclear membrane proteins to form the nuclear lamina on the interior of the nuclear envelope lamins have elastic and mechanosensitive properties and can alter gene regulation in a. Following modifications by ftase rce1 and icmt prelamin.
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